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孙允东
作者:  来源:  发布时间:2016-09-18 21:15:33  浏览次数:1354

、 基本情况:

孙允东,男,山东大学病原微生物教授,博士生导师,19775月出生2011年美国密歇根大学访问学者。《current microbiology, biomed research international》与《molecular biology reports》杂志审稿人,国家自然基金委函审专家。山东省微生物与免疫学会会员。   

QQ:328366628

研究方向:幽门螺杆菌耐药机制;消化道菌群与健康

二、 科研成果

(一) 承担课题

1、 SpoT(ppGpp)调控幽门螺杆菌适应抗生素压力分子机制研究(81471991),国家自然基金面上项目,72万,2015-2018

2、 压力加重幽门螺杆菌胃炎分子机制研究(81671978),国家自然基金面上项目,70万,2017-2020

3、 幽门螺杆菌SpoT基因适应INF-γ表达调控机制研究(81071313),国家自然基金面上项目,32万,2011-2013

4、 SpoT调控幽门螺旋杆菌氧应激严谨应答分子机制研究(30800037),国家自然基金青年基金,20万,2009-2011

5、 σ54调控幽门螺杆菌平台期氧损伤分子机制研究(中国博士后特别资助),10万,2010-2011

(二) 发表论文(*:通讯作者,#:共同第一)

 1Sun Y, Zhang M, Chen CC, Gillilland M 3rd, Sun X, El-Zaatari M, Huffnagle GB, Young VB, Zhang J, Hong SC, Chang YM, Gumucio DL, Owyang C, Kao JY*. Stress-induced corticotropin-releasing hormone-mediated NLRP6 inflammasome inhibition and transmissible enteritis in mice. Gastroenterology. 144(7):1478-87, 1487.e1-8; 2013 Jun.(消化类杂志排名第一,IF=18.18

2Geng X, Li W, Chen Z, Gao S, Hong W, Ge X, Hou G, Hu Z, Zhou Y, Zeng B, Li W, Jia J, Sun Y*.Bifunctional enzyme SpoT is involved in the clarithromycin tolerance of Helicobacter pylori by up-regulating the transporters HP0939, HP1017, HP0497, and HP0471.Antimicrob Agents Chemother(微生物耐药研究TOP期刊. 2017 Feb 27. pii: AAC.02011-16. doi: 10.1128/AAC.02011-16. [Epub ahead of print]

3Zhekai Hu, Yu Zhang, Zhiyu Li, Yuedi Yu, Wenyan Kang, Yingnan Han, Xiwen Geng, Shaohua Ge*, Yundong Sun*.Effect of Helicobacter pylori infection on chronic periodontitis by the change of microecology and inflammation.Oncotarget.2016 August 20.doi: 10.18632 /oncotarget.9573.

4Yuqun Shan, Xingxiao Lu, Yingnan Han, Xinpeng Li, Xiao Wang, Chunhong Shao,Lixiang Wang, Zhifang Liu, Wei Tang, Yundong Sun* and Jihui Jia. Helicobacter pylori Outer Membrane Protein 18 (Hp1125) Is Involved in Persistent Colonization by Evading Interferon-γ Signaling. Biomed Res Int. 2015;2015:571280. doi: 10.1155/2015/571280. Epub 2015 Apr 6 

5、Sun Y#*, Liu S#, Li W, Shan Y, Li X, Lu X, Li Y, Guo Q, Zhou Y, Jia J*. Proteomic analysis of the function of sigma factor σ54 in Helicobacter pylori survival with nutrition deficiency stress in vitro. PLoS One. 8(8):e72920;2013 Aug 28. doi: 10.1371

6Sun Y, Li X, Li W, Zhao M, Wang L, Liu S, Zeng J, Liu Z, Jia J*. Proteomic analysis of the function of SpoT in Helicobacter pylori anti-oxidative stress in vitro and colonization in vivo. J Cell Biochem.113(11):3393-402; 2012 Nov. 

7Sun YD, Fu LD, Jia YP, Du XJ, Wang Q, Wang YH, Zhao XF, Yu XQ, Wang JX. A hepatopancreas-specific C-type lectin from the Chinese shrimp Fenneropenaeus chinensis exhibits antimicrobial activity. Mol Immunol. 2008 Jan;45(2):348-61. Epub 2007 Aug 6.

8Sun YD, Zhao XF, Kang CJ, Wang JX. Molecular cloning and characterization of Fc-TSP from the Chinese shrimp Fennerpenaeus chinensis. Mol Immunol. 2006 Mar;43(8):1202-10. Epub 2005 Aug 18

9Shao, Chunhong#Sun, Yundong#, Wang, Na, Yu, Han, Zhou, Yabin, Chen, Chunyan, Jia, Jihui* Changes of proteome components of Helicobacter pylori biofilms induced by serum starvation. Molecular Medicine Reports, 8(6), pp 1761-1766, 2013/12.

10Wang H#, Sun Y#, Liu S, Yu H, Li W, Zeng J, Chen C, Jia J *. Upregulation of progranulin by Helicobacter pylori in human gastric epithelial cells via p38MAPK and MEK1/2 signaling pathway: role in epithelial cell proliferation and migration. FEMS Immunol Med Microbiol, 63(1), pp 82-92.(它引9次)

11Liu S#, Sun Y#, Li W, Yu H, Li X, Liu Z, Zeng J, Zhou Y, Chen C, Jia J.The antibacterial mode of action of allitridi for its potential use as a therapeutic agent against Helicobacter pylori infection(2009). FEMS Microbiol Lett. 2010 Feb 1;303(2):183-9(它引7次)

12Yu-Ping Jia#Yun-Dong Sun# Qian Wang, Xiao-fan Zhao, Jin-Xing Wang.A single whey acidic protein domain (SWD)-containing peptide from the fleshy prawn with antimicrobial and proteinase inhibition activities. AquacultureVolume 284, Issues 1-4, 1 November 2008, Pages 246-259(它引42次)

三、教学成果

1、医学微生物学山东省精品课程骨干成员。

22014年山东大学中青年教师讲课比赛优秀奖。

3、作为医学微生物系中青年教学骨干教师参加山东大学教学与促进发展中心举办的教学能力提升研修班。

4、山东省微课比赛三等奖

5、全国医学类微课比赛鼓励奖

四、其它工作 (指导本科生创新实验)

1、指导口腔学院校长奖学金获得者马驷骎大学生创新实验

2、指导口腔学院本本科生胡哲凯等大学生创新实验,并在《oncotarget》发表文章

3、指导医学院七年制学生赵朗等大学生创新实验

4、指导医学院六年制本科生崔岳被宾夕法尼亚大学录取为全额奖学金博士生

5、指导口腔学院本科生李淑彤,荣兴等获得国家级大学生创新项目

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