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贾继辉
作者:  来源:  发布时间:2016-09-18 20:59:08  浏览次数:1415

一、基本信息                                                                            
姓    名:贾继辉
性    别:男
出生日期:1963年01月
文化程度:医学博士
专业职称:教授,博士生导师
研究方向:感染炎症与胃癌

学术任职:

世界卫生组织脆弱关怀合作中心 (主 任)                                   

山东大学-卡罗林斯卡医学院肿瘤合作研究实验室 (主 任)             

山东大学齐鲁医学部基础医学院病原生物学系 (主 任)                 

中华医学会微生物学与免疫学专业委员会 (常 委)                        

中国微生物学会(理 事)                                                        

山东医学会微生物学与免疫学专业委员会(主 任)                         

山东微生物学会医学专业委员会(主 任)                                   

国家自然科学基金医学科学领域学科会议评审组(专 家)             

山东省自然科学基金医学评审组(组 长)                                      

行政任职:山东大学齐鲁医学部副部长(分管人才培养与学科建设)

联系电话:13853186075,0531-88382672

电子邮箱:jiajihui@sdu.edu.cn

二、在研科研项目(主持)

1、国家973重大科学计划:端粒相关蛋白在基因表达调控及细胞分化中的作用,2012.01-2017.01560万元

2、国家自然科学基金项目:幽门螺杆菌感染向恶性转化演进中网络调控节点分子HNF4a的致病机制研究2014.01-2016.1280万元

3、国家自然科学基金项目:RNA结合蛋白LIN28A介导幽门螺杆菌感染恶性转化的调控机制2016.01-2018.1284万元

4国家自然科学基金项目(国际合作:中国/瑞典):端粒酶、肿瘤干细胞和肿瘤发育/进展:靶向端粒酶的肿瘤治疗策略,2016.01-2017.12

三、代表性学术论文

1. Zeng J, Ge Z, Wang L, Li Q, Wang N, Björkholm M, Jia J(贾继辉共同通讯作者), Xu D. The histone demethylase RBP2 Is overexpressed in gastric cancer and its inhibition triggers senescence of cancer cells. Gastroenterology. 2010 Mar;138(3):981-92. (影响因子18.187 )

2. Zhao L, Li W, Zang W, Liu Z, Xu X, Yu H, Yang Q, Jia J(贾继辉通讯作者). JMJD2B Promotes Epithelial-Mesenchymal Transition by Cooperating with β-Catenin and Enhances Gastric Cancer Metastasis. Clin Cancer Res. 2013 Dec 1;19(23):6419-29. (影响因子8.193

3. Li W, Ge Z, Liu C, Liu Z, Björkholm M, Jia J(贾继辉通讯作者), Xu D. CIP2A is overexpressed in gastric cancer and its depletion leads to impaired clonogenicity, senescence, or differentiation of tumor cells. Clin Cancer Res. 2008 Jun 15;14(12):3722-8.  (影响因子8.193 )

        4. Liu ZLi QLi KChen LLi WHou MLiu TYang JLindvall CBjörkholm MJia J Jia J(贾继辉共同通讯作者)Xu D. Telomerase reverse transcriptase promotes epithelial-mesenchymal transition and stem cell-like traits in cancer cells. Oncogene. 2013 Sep 5;32(36):4203-4213. (影响因子8.559

5. Ma L, Zeng J, Guo Q, Liang X, Shen L, Li S, Sun Y, Li W, Liu S, Yu H, Chen C, Jia J(贾继辉通讯作者). Mutual amplification of HNF4α and IL-1R1 composes an inflammatory circuit in Helicobacter pylori associated gastric carcinogenesis. Oncotarget. 2016 Feb 8;7(10):11349-63.(影响因子6.368

6. Liang X, Zeng J, Wang L, Shen L, Ma X, Li S, Wu Y, Ma L, Ci X, Guo Q, Jia M, Shen H, Sun Y, Liu Z, Liu S, Li W, Yu H, Chen C, Jia J(贾继辉通讯作者).  Histone demethylase RBP2 promotes malignant progression of gastric cancer through TGF-β1-(p-Smad3)-RBP2-E-cadherin-Smad3 feedback circuit. Oncotarget. 2015 Jul 10;6(19):17661-74. (影响因子6.368

7. Liang X, Zeng J, Wang L, Shen L, Li S, Ma L, Ci X, Yu J, Jia M, Sun Y, Liu Z, Liu S, Li W, Yu H, Chen C, Jia J(贾继辉通讯作者). Histone demethylase RBP2 induced by Helicobactor Pylori CagA participates in the malignant transformation of gastric epithelial cells. Oncotarget. 2014 Jul 30;5(14):5798-807. (影响因子6.627

8. Ci X, Li B, Ma X, Kong F, Zheng C, Björkholm M, Jia J(贾继辉共同通讯作者), Xu D. Bortezomib-mediated down-regulation of telomerase and disruption of telomere homeostasis contributes to apoptosis of malignant cells. Oncotarget. 2015 Nov 10;6(35):38079-92. (影响因子6.368

 9. Liu T, Liang X, Li B, Björkholm M, Jia J(贾继辉共同通讯作者), Xu D. Telomerase reverse transcriptase inhibition stimulates cyclooxygenase 2 expression in cancer cells and synergizes with celecoxib to exert anti-cancer effects. Br J Cancer. 2013 Jun 11;108(11):2272-80. (影响因子5.569

10. Li W, Li L, Liu Z, Liu C, Liu Z, Strååt K, Björkholm M, Jia J(贾继辉通讯作者), Xu D. Expression of the full-length telomerase reverse transcriptase (hTERT) transcript in both malignant and normal gastric tissues. Cancer Lett. 2008 Feb 18;260(1-2):28-36. (影响因子5.992

11. Li W, Zeng J, Li Q, Zhao L, Liu T, Björkholm M, Jia J(贾继辉共同通讯作者), Xu D. Reptin is required for the transcription of telomerase reverse transcriptase and over-expressed in gastric cancer. Mol Cancer. 2010 May 30;9:132. (影响因子5.888

12. Zeng J, Wang L, Li Q, Li W, Björkholm M, Jia J(贾继辉共同通讯作者), Xu D. FoxM1 is up-regulated in gastric cancer and its inhibition leads to cellular senescence, partially dependent on p27 kip1. J Pathol. 2009 Aug;218(4):419-27. (影响因子7.381

13. Xu X, Zhang Y, Liu Z, Zhang X, Jia J(贾继辉通讯作者). miRNA-532-5p functions as an oncogenic microRNA in human gastric cancer by directly targeting RUNX3. J Cell Mol Med. 2016 Jan;20(1):95-103. (影响因子4.938

14. Liu Z, Chen L, Zhang X, Xu X, Xing H, Zhang Y, Li W, Yu H, Zeng J, Jia J (贾继辉通讯作者). RUNX3 regulates vimentin expression via miR-30a during epithelial-mesenchymal transition in gastric cancer cells. J Cell Mol Med. 2014 Apr;18(4):610-23. (影响因子4.014

 15. Feng Y, Wang L, Zeng J, Shen L, Liang X, Yu H, Liu S, Liu Z, Sun Y, Li W, Chen C, Jia J(贾继辉通讯作者). Forkhead box M1 is overexpressed in Helicobacter pylori-induced gastric carcinogenesis and is negatively regulated by hsa-miR-370. Mol Cancer Res. 2013 Aug; 11(8):834-44. (影响因子4.502

16. Yang Q, Wang B, Gao W, Huang S, Liu Z, Li W, Jia J(贾继辉通讯作者)SIRT1 Is Downregulated in Gastric Cancer and Leads to G1-phase Arrest via NF-κB/Cyclin D1 Signaling. Mol Cancer Res. 2013 Dec;11(12):1497-507 (影响因子4.502

17. Zhou Y, Wang G, Li Y, Liu Y, Song Y, Zheng W, Zhang N, Hu X, Yan S, Jia J(贾继辉通讯作者). In vitro interactions between aspirin and amphotericin B against planktonic cells and biofilm cells of Candida albicans and C. parapsilosis. Antimicrob Agents Chemother. 2012 Jun;56(6):3250-60. (影响因子4.565

18. Liu Z, Zhang X, Xu X, Chen L, Li W, Yu H, Sun Y, Zeng J, Jia J(贾继辉通讯作者). RUNX3 inhibits survivin expression and induces cell apoptosis in gastric cancer. Eur J Cell Biol. 2014 Mar;93(3):118-26(影响因子3.825

19. Yang Q, Wang B, Zang W, Wang X, Liu Z, Li W, Jia J(贾继辉通讯作者)Resveratrol inhibits the growth of gastric cancer by inducing g1 phase arrest and senescence in a sirt1-dependent manner. PLoS One. 2013 Nov 21;8(11):e70627. 影响因子3.534

20. Sun Y, Liu S, Li W, Shan Y, Li X, Lu X, Li Y, Guo Q, Zhou Y, Jia J贾继辉通讯作者Proteomic analysis of the function of sigma factor σ54 in Helicobacter pylori survival with nutrition deficiency stress in vitro. PLoS One. 2013 Aug 28;8(8):e72920. (影响因子3.534 

21. Yu H, Zeng J, Liang X, Wang W, Zhou Y, Sun Y, Liu S, Li W, Chen C, Jia J(贾继辉通讯作者). Helicobacter pylori promotes epithelial-mesenchymal transition in gastric cancer by downregulating programmed cell death protein 4 (PDCD4). PLoS One. 2014 Aug 21;9(8):e105306.(影响因子3.234

22. Zeng J, Fang M, Wang L, Liang X, Shan Y, Yu H, Liu Z, Sun Y, Liu S, Chen C, Jia J(贾继辉通讯作者). MicroRNA-212 inhibits proliferation of gastric cancer by directly repressing retinoblastoma binding protein 2. J Cell Biochem. 2013 Dec;114(12):2666-72. (影响因子3.263

23. Sun Y, Liu S, Li W, Shan Y, Li X, Lu X, Li Y, Guo Q, Zhou Y, Jia J(贾继辉通讯作者). Proteomic analysis of the function of sigma factor σ54 in Helicobacter pylori survival with nutrition deficiency stress in vitro. PLoS One. 2013 Aug 28;8(8):e72920. (影响因子3.534

24. Han M, Xu J, Bi Y, Jiang M, Xu X, Liu Q, Jia J(贾继辉通讯作者). Primary tumor regulates the pulmonary microenvironment in melanoma carcinoma model and facilitates lung metastasis. J Cancer Res Clin Oncol. 2013 Jan;139(1):57-65. (影响因子3.009

25. Sun Y, Li X, Li W, Zhao M, Wang L, Liu S, Zeng J, Liu Z, Jia J(贾继辉通讯作者). Proteomic analysis of the function of spot in Helicobacter pylori anti-oxidative stress in vitro and colonization in vivo. J Cell Biochem. 2012 Nov;113(11):3393-402. (影响因子3.062

26. Liu Z, Xu X, Chen L, Li W, Sun Y, Zeng J, Yu H, Chen C, Jia J(贾继辉通讯作者). Helicobacter pylori CagA inhibits the expression of Runx3 via Src/MEK/ERK and p38 MAPK pathways in gastric epithelial cell. J Cell Biochem. 2012 Mar;113(3):1080-6. (影响因子3.062

 
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